Developments and innovations continued into the 21st century. The Brand expanded its portfolio of movements: in 2001, it introduced a movement with a new patented date display system, with a large window and a moon phase indicator.

Renewing its key role in the history of the quartz watch, the Brand unveiled a new family of movements employing this technology. In 2006, it added the calibre GP2700 (19.4 mm) and GP4500 (30 mm) to its portfolio of self-winding mechanical movements.
It also developed its collections: in 2000 the ww.tc model was presented, featuring the ingenious and elegant combination of a chronograph with a world time indicator; a new design for Sea Hawk diving watches in 2002; the launch of a line of ultra-feminine watches fitted with mechanical complication movements, with the Cat's Eye in 2004.

Girard-Perregaux indulged the art of Haute Horlogerie, unveiling new interpretations of some of its flagship models: the innovative Laureato Evo3 Tourbillon with three sapphire Bridges in 2006, and the Vintage 1945 Jackpot Tourbillon in 2007 were two examples. The Brand was also responsible for two world firsts: a perpetual calendar combined with world times (2006) and the Split Second Jumping Second Chronograph Tourbillon (2008).

More than ever focused on innovation, it unveiled a spectacular development in 2008: a movement fitted with a constant force escapement dubbed the "Constant Escapement". Revolutionary in every respect, it opened the way for the creation of Haute Horlogerie mechanisms of unrivalled precision.
